Journal Article

Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians

Jian Gu, Yubo Gong, Maosheng Huang, Charles Lu, Margaret R. Spitz and Xifeng Wu

in Carcinogenesis

Volume 28, issue 2, pages 350-355
Published in print August 2006 | ISSN: 0143-3334
Published online February 2007 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgl149
Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians

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STK15/Aurora-A is a centrosome-localized serine/threonine kinase that functions primarily in centrosome maturation and mitotic spindle assembly. In a large lung cancer case–control study of 1401 cases and 1397 controls including three ethnic groups, we examined the associations between two non-synonymous SNPs (Phe31Ile and Val57Ile) of the STK15 gene and lung cancer risk. There were statistically significant differences in the distribution of the genotypes (P < 0.0001) and haplotypes (P < 0.0001) by ethnicity for the Phe31Ile, but not the Val57Ile variant. Caucasians with the homozygous variant Phe31Ile genotype (Ile/Ile) were at a significantly reduced risk for lung cancer [odds ratio (OR) = 0.63, 95% confidence interval (CI) = 0.41–0.96]. The variant allele of Val57Ile was not associated with lung cancer risk overall. However, men with the homozygous variant genotype (Ile/Ile) had a reduced lung cancer risk as compared with men with the wild-type genotype (Val/Val) (OR = 0.42, 95% CI = 0.19–0.94). When we performed joint analysis of these two polymorphisms, compared with the reference group (TT + GG, 40.99% of controls), homozygous Ile31 allele/wild-type Val57 allele (AA + GG) carriers (5.45% of controls) exhibited a reduced lung cancer risk (OR = 0.78, 95% CI = 0.63–0.97). This is the first epidemiological study to report significant associations between STK15 polymorphisms and lung cancer risk.

Journal Article.  5119 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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