Journal Article

Peroxisome profilerator-activated receptorγ2 Pro<sup>12</sup>Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes

Ulla Vogel, Jane Christensen, Bjørn A Nexø, Håkan Wallin, Søren Friis and Anne Tjønneland

in Carcinogenesis

Volume 28, issue 2, pages 427-434
Published in print September 2006 | ISSN: 0143-3334
Published online February 2007 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgl170
Peroxisome profilerator-activated receptorγ2 Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes

More Like This

Show all results sharing this subject:

  • Clinical Cytogenetics and Molecular Genetics

GO

Show Summary Details

Preview

Use of non-steroid anti-inflammatory drugs (NSAIDs) has been associated with decreased risk of breast cancer in epidemiological studies. Thus, a high-inflammatory response may be associated with increased breast cancer risk. It is thus possible that genetic variations leading to a modified inflammatory response will influence breast cancer risk. The purpose of this study was to determine if polymorphisms associated with an altered inflammatory response are associated with breast cancer risk, and to investigate the possible interaction with lifestyle factors such as alcohol use, smoking and NSAID use. We matched 361 female breast cancer cases with 361 controls, nested within the prospective ‘Diet, Cancer and Health’ study. Carriers of the variant Ala-allele of PPARγ2 Pro12Ala were at lower risk of breast cancer (IRR = 0.67, 95% CI = 0.46–0.97). This was primarily due to an interaction with alcohol consumption. Alcohol consumption was associated with a 1.21-fold increased risk of breast cancer per 10 g alcohol/day (95% CI = 1.06–1.35) among homozygous wild-type carriers, whereas alcohol was not associated with breast cancer risk among variant allele carriers (P for interaction = 0.005). Non-users of NSAID, who were carriers of the variant allele of PPARγ2 Pro12Ala, were at lower risk of breast cancer (IRR = 0.44; 95% CI = 0.26–0.73) compared with non-users carrying wild-type alleles (P for interaction = 0.03). No effects were found for IL6 G-174C, IL8 T-251A and COX2 T8473C. Our results suggest that PPARγ2 Pro12Ala is an important determinant in alcohol mediated breast carcinogenesis. We also observe interaction between NSAID, alcohol consumption and PPARγ2 Pro12Ala genotype in relation to breast cancer risk.

Journal Article.  6154 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.