Journal Article

Apigenin inhibits tumor angiogenesis through decreasing HIF-1α and VEGF expression

Jing Fang, Qiong Zhou, Ling-Zhi Liu, Chang Xia, Xiaowen Hu, Xianglin Shi and Bing-Hua Jiang

in Carcinogenesis

Volume 28, issue 4, pages 858-864
Published in print October 2006 | ISSN: 0143-3334
Published online April 2007 | e-ISSN: 1460-2180 | DOI: https://dx.doi.org/10.1093/carcin/bgl205
Apigenin inhibits tumor angiogenesis through decreasing HIF-1α and VEGF expression

More Like This

Show all results sharing this subject:

  • Clinical Cytogenetics and Molecular Genetics

GO

Show Summary Details

Preview

Apigenin is a non-toxic dietary flavonoid with anti-tumor properties. We recently showed that apigenin-inhibited hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression in human ovarian cancer cells under normoxic condition. However, the effect of apigenin in angiogenesis remains to be elucidated. Angiogenesis is the formation of new blood vessels and is required for tumor growth and metastasis. In this study, we showed that apigenin-inhibited expression of HIF-1 and VEGF in different cancer cells under both normoxic and hypoxic conditions. We demonstrated that apigenin significantly inhibited tumor angiogenesis in vivo, by using both the chicken chorioallantoic membrane and Matrigel plug assays. The inhibition of tumor angiogenesis was associated with the decrease of HIF-1 and VEGF in tumor tissues. Taken together, our results show that apigenin suppresses tumor angiogenesis through HIF-1 and VEGF expression.

Journal Article.  4688 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.