Journal Article

Control of virus infection by tumour suppressors

César Muñoz-Fontela, María A. García, Manuel Collado, Laura Marcos-Villar, Pedro Gallego, Mariano Esteban and Carmen Rivas

in Carcinogenesis

Volume 28, issue 6, pages 1140-1144
Published in print June 2007 | ISSN: 0143-3334
Published online March 2007 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgm048
Control of virus infection by tumour suppressors

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An increasing number of tumour suppressor genes are induced by interferons (IFNs) and may play an important role in the control of cell proliferation induced by this cytokine. In addition, pathways triggered by both tumour suppressors and IFN converge as common targets for non-related tumour viruses. The inhibition of the IFN response by animal viruses is explained by the fundamental role that IFN plays to control virus infection. However, the reasons why many viruses, including those that do not require the replication of the host, target tumour suppressor pathways are varied and are still under investigation. Here we review those findings that support that tumour suppressors may have a role in the control of virus infection.

Journal Article.  3619 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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