Journal Article

Role of angiotensinogen gene polymorphism on <i>Helicobacter pylori</i> infection-related gastric cancer risk in Japanese

Mitsushige Sugimoto, Takahisa Furuta, Naohito Shirai, Chise Kodaira, Masafumi Nishino, Mutsuhiro Ikuma, Haruhiko Sugimura and Akira Hishida

in Carcinogenesis

Volume 28, issue 9, pages 2036-2040
Published in print September 2007 | ISSN: 0143-3334
Published online March 2007 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgm074
Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese

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Backgrounds and aims: The renin–angiotensin (RA) system including angiotensinogen (AGT), angiotensin I and angiotensin II influences the regulation of cell proliferation, angiogenesis and inflammation. AGT-20 A/C polymorphism is associated with the plasma AGT and angiotensin II levels. The aim of this study was to clarify the association of AGT-20 A/C polymorphism with susceptibility to gastric cancer and peptic ulcer in Japanese. Methods: We assessed the AGT-20 A/C polymorphism in Helicobacter pylori-positive patients with gastric cancer (n = 135), gastric ulcer (n = 148) and duodenal ulcer (n = 113) and controls (n = 292) consisting of H.pylori-positive gastritis alone (n = 160) and H.pylori-negative subjects (n = 132). Results: The age- and sex-adjusted odds ratios (ORs) of AGT-20 A/C and C/C genotypes relative to A/A genotype for gastric cancer risk were 1.695 [95% confidence interval (CI): 1.035–2.777] and 2.259 (95% CI: 0.351–14.533), respectively. The AGT-20 C allele increased the gastric cancer risk (OR: 1.685, 95% CI: 1.037–2.736), especially the intestinal type of gastric cancer (OR: 1.792, 95% CI: 1.040–3.089). However, there was no association between the AGT-20 polymorphism and susceptibility to peptic ulcer. Conclusions: The carriage of AGT-20 C allele was associated with an increased risk for H.pylori-related gastric cancer development in Japanese, indicating that the RA system plays an important role in the pathogenesis of gastric cancer.

Journal Article.  3593 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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