Journal Article

Cancer genomics: integrating form and function

So Young Kim and William C. Hahn

in Carcinogenesis

Volume 28, issue 7, pages 1387-1392
Published in print July 2007 | ISSN: 0143-3334
Published online April 2007 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgm086
Cancer genomics: integrating form and function

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The sequencing of the human genome has formed the foundation with which to develop technologies and reagents to perform true genome-scale biological studies. In particular, the development and increasing application of these high-throughput genome-scale technologies have fundamentally altered the way one can approach the analysis of cancer. It is now possible to imagine studies that interrogate the structure, expression and function of every gene in a comprehensive, highly parallel fashion, permitting the development of multidimensional, global views of cancer. In this review, we focus on recent advances in the application of genomic strategies to the study of cancer, with an emphasis on functional genomics and the prospects for integrating the knowledge gained from these approaches to further develop our understanding of cancer and design better therapeutic strategies.

Journal Article.  5439 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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