Journal Article

Compounds from <i>Wedelia chinensis</i> synergistically suppress androgen activity and growth in prostate cancer cells

Feng-Min Lin, Li-Ru Chen, En-Hau Lin, Ferng-Chun Ke, Hsin-Yi Chen, Meng-Jen Tsai and Pei-Wen Hsiao

in Carcinogenesis

Volume 28, issue 12, pages 2521-2529
Published in print December 2007 | ISSN: 0143-3334
Published online October 2007 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgm137
Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells

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Chronic inflammation can augment tumor development in various types of cancers, including prostate cancer (PCa). Reduction of inflammation is therefore an important anticancer therapeutic opportunity. Here, we report four anti-proliferative phytocompounds in Wedelia chinensis, an oriental herbal medicine, identified through their ability to modulate the androgen receptor (AR) activation of transcription from prostate-specific antigen promoter in PCa cells. The 50% inhibition concentration values of indole-3-carboxylaldehyde, wedelolactone, luteolin and apigenin, were 34.9, 0.2, 2.4 and 9.8 μM, respectively. A formula that combined the phytocompounds in the same proportions as in the herbal extract decreased the dosage of each compound required to achieve maximal AR inhibition. In correlation with the AR suppression effect, these active compounds specifically inhibited the growth of AR-dependent PCa cells and as a combination formula they also synergistically suppressed growth in AR-dependent PCa cells. Our study has identified synergistic effects of active compounds in W. chinensis and demonstrated their potential in PCa prevention and therapy. The paradigm of multiple activities and synergism is a useful framework to investigate the therapeutic effects of whole extracts from assorted medicinal plant species.

Journal Article.  5660 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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