Journal Article

COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men

Pedro Fernandez, Pieter M. de Beer, Lize van der Merwe and Chris F. Heyns

in Carcinogenesis

Volume 29, issue 12, pages 2347-2350
Published in print December 2008 | ISSN: 0143-3334
Published online October 2008 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgn245
COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men

More Like This

Show all results sharing this subject:

  • Clinical Cytogenetics and Molecular Genetics

GO

Show Summary Details

Preview

Cyclooxygenase-2 (COX-2) converts arachidonic acid to prostaglandins, which are important mediators of cell proliferation and inflammation. Evidence indicates that COX-2 plays a role in carcinogenesis and that it is over-expressed in prostate tumours. We investigated the role of COX-2 variants in prostate cancer in a case–control study of South African Coloured men, consisting of 151 cases and 134 controls. The genotype frequencies of four single-nucleotide polymorphisms (SNPs) in the COX-2 promoter were initially determined in 50 control subjects. One SNP, rs20417 (−899G>C), was monomorphic and excluded from further investigation. Three SNPs, rs3918304 (−1285A>G), rs20415 (−1265C>T) and rs5270 (−297C>G), were genotyped in all the case patients and control subjects. The −1285 G-allele and −1265 T-allele were associated with increased risk of prostate cancer [odds ratio (OR) = 3.53; confidence interval (CI) = 2.14–5.90; P < 0.0001 and OR = 3.01; CI = 1.82–5.02; P < 0.0001] after adjusting for age. Haplotype GTC conferred increased risk of prostate cancer in South African Coloured men (OR = 3.54 versus ACC; CI = 2.12–5.92; P < 0.0001). These findings in conjunction with findings in other populations of African descent might suggest a common causal variant for prostate cancer in COX-2, or a variant in a nearby gene.

Journal Article.  2837 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.