Journal Article

Human <i>RIF1</i> encodes an anti-apoptotic factor required for DNA repair

Haibo Wang, Ailian Zhao, Lin Chen, Xueyan Zhong, Ji Liao, Min Gao, Minghua Cai, Dong-Hyun Lee, Jing Li, Dipanjan Chowdhury, Yun-gui Yang, Gerd P. Pfeifer, Yun Yen and Xingzhi Xu

in Carcinogenesis

Volume 30, issue 8, pages 1314-1319
Published in print August 2009 | ISSN: 0143-3334
Published online May 2009 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgp136
Human RIF1 encodes an anti-apoptotic factor required for DNA repair

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Human Rap1-interacting protein 1 (RIF1) contributes to the ataxia telangiectasia, mutated-mediated DNA damage response against the dexterous effect of DNA lesions and plays a critical role in the S-phase checkpoint. However, the molecular mechanisms by which human RIF1 conquers DNA aberrations remain largely unknown. We here showed that inhibition of RIF1 expression by small interfering RNA led to defective homologous recombination-mediated DNA double-strand break repair and sensitized cancer cells to camptothecin or staurosporine treatment. RIF1 underwent caspase-dependent cleavage upon apoptosis. We further found that RIF1 was highly expressed in human breast tumors, and its expression status was positively correlated with differentiation degrees of invasive ductal carcinoma of the breast. Our results suggest that RIF1 encodes an anti-apoptotic factor required for DNA repair and is a potential target for cancer treatment.

Journal Article.  4147 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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