Journal Article

Involvement of p29 in DNA damage responses and Fanconi anemia pathway

Po-Chen Chu, Tao-Yeuan Wang, Yen-Ta Lu, Chuan-Kai Chou, Yuh-Cheng Yang and Mau-Sun Chang

in Carcinogenesis

Volume 30, issue 10, pages 1710-1716
Published in print October 2009 | ISSN: 0143-3334
Published online September 2009 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgp204
Involvement of p29 in DNA damage responses and Fanconi anemia pathway

More Like This

Show all results sharing this subject:

  • Clinical Cytogenetics and Molecular Genetics

GO

Show Summary Details

Preview

Human p29 is a chromatin-associated protein and the silencing of p29 expression increases cell population in G1 phase and decreases phosphorylation levels of Chk1 and Chk2 in response to UV treatment. To further characterize the function of p29, U2OS and Fanconi anemia complementation group G (FA-G) cells with constitutive p29 expression have been established. Analyses of these cells identified increased phosphorylation levels of Chk1 and Chk2, which were accompanied by elevated amounts of chromatin-associated Mre11–Rad50–Nbs1 complex and ATR-IP. Monoubiquitination of the FA ID complex was restored in p29 stably expressing FA-G cells. Moreover, lower tumor incidence was observed in mp29 transgenic mice after UV irradiation. These results suggest the involvement of p29 in the DNA damage responses and Fanconi anemia pathway.

Journal Article.  4971 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.