Journal Article

The extracellular loop 2 of TM4SF5 inhibits integrin α2 on hepatocytes under collagen type I environment

Sin-Ae Lee, Young Mee Kim, Tae Kyoung Kwak, Hyeon Jung Kim, Semi Kim, Wonil Ko, Sung-Hoon Kim, Ki Hun Park, Hyun Jeong Kim, Moonjae Cho and Jung Weon Lee

in Carcinogenesis

Volume 30, issue 11, pages 1872-1879
Published in print November 2009 | ISSN: 0143-3334
Published online September 2009 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgp234
The extracellular loop 2 of TM4SF5 inhibits integrin α2 on hepatocytes under collagen type I environment

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Four-transmembrane L6 family member 5 (TM4SF5) and its homolog L6, a tumor antigen, form a four-transmembrane L6 family. TM4SF5 expression causes uncontrolled cell proliferation and angiogenesis. Although other genuine transmembrane 4 superfamily (TM4SF) members co-operate with integrins for cell migration, roles of TM4SF5 in the cellular spreading and migration are unknown. Using hepatocarcinoma cell clones that ectopically express TM4SF5, we found that cross talks via an extracellular interaction between TM4SF5 and integrin α2 in collagen type I environment inhibited integrin α2 functions such as spreading on and migration toward collagen I, which were recovered by suppression of TM4SF5 or structural disturbance of its second extracellular loop using a peptide or mutagenesis. Altogether, the observations suggest that TM4SF5 in hepatocytes negatively regulates integrin α2 function via an interaction between the extracellular loop 2 of TM4SF5 and integrin α2 during cell spreading on and migration through collagen I environment.

Journal Article.  4803 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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