Journal Article

Individuals susceptible to lung adenocarcinoma defined by combined <i>HLA-DQA1</i> and <i>TERT</i> genotypes

Takashi Kohno, Hideo Kunitoh, Yoko Shimada, Kouya Shiraishi, Yuko Ishii, Koichi Goto, Yuichiro Ohe, Yutaka Nishiwaki, Aya Kuchiba, Seiichiro Yamamoto, Hiroshi Hirose, Akira Oka, Noriko Yanagitani, Ryusei Saito, Hidetoshi Inoko and Jun Yokota

in Carcinogenesis

Volume 31, issue 5, pages 834-841
Published in print May 2010 | ISSN: 0143-3334
Published online January 2010 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgq003
Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes

More Like This

Show all results sharing this subject:

  • Clinical Cytogenetics and Molecular Genetics

GO

Show Summary Details

Preview

Adenocarcinoma (ADC) is the commonest histological type of lung cancer, and its weak association with smoking indicates the necessity to identify high-risk individuals for targeted screening and/or prevention. By a genome-wide association study (GWAS), we identified an association of polymorphisms in the 6p21.31 locus containing four human leukocyte antigen (HLA) class II genes with lung ADC risk. DQA1*03 of the HLA-DQA1 gene was defined as a risk allele with odds ratio (OR) of 1.36 [95% confidence interval (CI) = 1.21–1.54, P = 5.3 × 10−7] by analysis of 1656 ADC cases and 1173 controls. DQA1*03 and the minor allele for a polymorphism, rs2736100, in TERT, another lung cancer susceptibility locus identified in recent GWASs on Europeans and Americans, were indicated to independently contribute to ADC risk with per allele OR of 1.43 (95% CI = 1.31–1.56, P = 7.8 × 10−16). Individuals homozygous both for the DQA1*03 and minor TERT alleles were defined as high-risk individuals with an OR of 4.76 (95% CI = 2.53–9.47, P = 4.2 × 10−7). The present results indicated that individuals susceptible to lung ADC can be defined by combined genotypes of HLA-DQA1 and TERT.

Journal Article.  6004 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.