Journal Article

Extract from Asteraceae<i> Brachylaena ramiflora</i> induces apoptosis preferentially in mutant p53-expressing human tumor cells

Masoud Karimi, Francesca Conserva, Salah Mahmoudi, Jan Bergman, Klas G. Wiman and Vladimir J.N. Bykov

in Carcinogenesis

Volume 31, issue 6, pages 1045-1053
Published in print June 2010 | ISSN: 0143-3334
Published online April 2010 | e-ISSN: 1460-2180 | DOI:
Extract from Asteraceae Brachylaena ramiflora induces apoptosis preferentially in mutant p53-expressing human tumor cells

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The p53 tumor suppressor gene is inactivated by point mutation in a large fraction of human tumors, allowing evasion of apoptosis and tumor progression. p53 mutation is often associated with increased resistance to therapy. Pharmacological reactivation of mutant p53 is an attractive therapeutic strategy. We previously identified p53 reactivation and induction of massive apoptosis, a low-molecular weight compound that suppresses the growth of cancer cells in a mutant p53-dependent manner. Here, we report the identification and characterization of an extract from the terrestrial plant Brachylaena ramiflora (Asteraceae) that preferentially induces apoptosis in human tumor cells expressing mutant p53. Further analysis of this extract and identification of active compounds may provide novel structural scaffolds for the development of mutant p53-targeting anticancer drugs.

Journal Article.  5521 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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