Journal Article

NG2-expressing glial precursor cells are a new potential oligodendroglioma cell initiating population in <i>N</i>-ethyl-<i>N</i>-nitrosourea-induced gliomagenesis

Anne Briançon-Marjollet, Laurent Balenci, Manuel Fernandez, François Estève, Jérôme Honnorat, Régine Farion, Marine Beaumont, Emmanuel Barbier, Chantal Rémy and Jacques Baudier

in Carcinogenesis

Volume 31, issue 10, pages 1718-1725
Published in print October 2010 | ISSN: 0143-3334
Published online July 2010 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgq154
NG2-expressing glial precursor cells are a new potential oligodendroglioma cell initiating population in N-ethyl-N-nitrosourea-induced gliomagenesis

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Gliomas are the most common primary brain tumor affecting human adults and remain a therapeutic challenge because cells of origin are still unknown. Here, we investigated the cellular origin of low-grade gliomas in a rat model based on transplacental exposure to N-ethyl-N-nitrosourea (ENU). Longitudinal magnetic resonance imaging coupled to immunohistological and immunocytochemical analyses were used to further characterize low-grade rat gliomas at different stages of evolution. We showed that early low-grade gliomas have characteristics of oligodendroglioma-like tumors and exclusively contain NG2-expressing slow dividing precursor cells, which express early markers of oligodendroglial lineage. These tumor-derived precursors failed to fully differentiate into oligodendrocytes and exhibited multipotential abilities in vitro. Moreover, a few glioma NG2+ cells are resistant to radiotherapy and may be responsible for tumor recurrence, frequently observed in humans. Overall, these findings suggest that transformed multipotent NG2 glial precursor cell may be a potential cell of origin in the genesis of rat ENU-induced oligodendroglioma-like tumors. This work may open up new perspectives for understanding biology of human gliomas.

Journal Article.  5796 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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