Journal Article

Mechanistic insight into the ability of American ginseng to suppress colon cancer associated with colitis

Xiangli Cui, Yu Jin, Deepak Poudyal, Alexander A. Chumanevich, Tia Davis, Anthony Windust, Anne Hofseth, Wensong Wu, Joshua Habiger, Edsel Pena, Patricia Wood, Mitzi Nagarkatti, Prakash S. Nagarkatti and Lorne Hofseth

in Carcinogenesis

Volume 31, issue 10, pages 1734-1741
Published in print October 2010 | ISSN: 0143-3334
Published online August 2010 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgq163
Mechanistic insight into the ability of American ginseng to suppress colon cancer associated with colitis

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We have recently shown that American ginseng (AG) prevents and treats mouse colitis. Because both mice and humans with chronic colitis have a high colon cancer risk, we tested the hypothesis that AG can be used to prevent colitis-driven colon cancer. Using the azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model of ulcerative colitis, we show that AG can suppress colon cancer associated with colitis. To explore the molecular mechanisms of the anticancer effects of AG, we also carried out antibody array experiments on colon cells isolated at a precancerous stage. We found there were 82 protein end points that were either significantly higher (41 proteins) or significantly lower (41 proteins) in the AOM + DSS group compared with the AOM-alone (control) group. In contrast, there were only 19 protein end points that were either significantly higher (10 proteins) or significantly lower (9 proteins) in the AOM + DSS + AG group compared with the AOM-alone (control) group. Overall, these results suggest that AG keeps the colon environment in metabolic equilibrium when mice are treated with AOM + DSS and gives insight into the mechanisms by which AG protects from colon cancer associated with colitis.

Journal Article.  7315 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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