Journal Article

The role of inflammation in HPV carcinogenesis

Enrique Boccardo, Ana P. Lepique and Luisa L. Villa

in Carcinogenesis

Volume 31, issue 11, pages 1905-1912
Published in print November 2010 | ISSN: 0143-3334
Published online September 2010 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgq176
The role of inflammation in HPV carcinogenesis

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The role of inflammation in human papillomavirus (HPV) infection and disease is complex since it involves responses capable of preventing initial infections, clearing those ongoing as well as promoting persistence and progression of associated lesions. Avoiding the immune response has been considered a key aspect of HPV persistence which is the main factor leading to HPV-related neoplasia. HPVs have evolved different ways of targeting immune signaling pathways. Moreover, host inflammatory response may promote lesion progression and affect tumor fate by diverse mechanisms including the direct participation of inflammatory cells. In this review, we discuss the interplay between HPV oncogenic proteins and an array of inflammatory responses that ultimately may lead to cancer.

Journal Article.  6691 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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