Journal Article

Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study

Catherine S. Healey, Shahana Ahmed, Tracy A. O’Mara, Kaltin Ferguson, Diether Lambrechts, Diego A. Garcia-Dios, Ignace Vergote, Frederic Amant, Kimberley Howarth, Maggie Gorman, Shirley Hodgson, Ian Tomlinson, Hannah P. Yang, Jolanta Lissowska, Louise A. Brinton, Stephen Chanock, Montserrat Garcia-Closas, Per Hall, Jianjun Liu, Mitul Shah, Paul D.P. Pharoah, Deborah J. Thompson, Timothy R. Rebbeck, Brian L. Strom, Alison M. Dunning, Douglas F. Easton and Amanda B. Spurdle

in Carcinogenesis

Volume 32, issue 12, pages 1862-1866
Published in print December 2011 | ISSN: 0143-3334
Published online September 2011 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgr214
Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study

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Recent large--scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11 928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.

Journal Article.  3843 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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