Journal Article

CD25<sup>+</sup> T cell depletion impairs murine squamous cell carcinoma development via modulation of antitumor immune responses

Rodrigo Nalio Ramos, Carine Ervolino Oliveira, Thais Helena Gasparoto, Tatiana Salles de Souza Malaspina, Eduardo Bertoli Belai, Karen Angélica Cavassani, Gustavo Pompermaier Garlet, João Santana da Silva and Ana Paula Campanelli

in Carcinogenesis

Volume 33, issue 4, pages 902-909
Published in print April 2012 | ISSN: 0143-3334
Published online February 2012 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgs103
CD25+ T cell depletion impairs murine squamous cell carcinoma development via modulation of antitumor immune responses

More Like This

Show all results sharing this subject:

  • Clinical Cytogenetics and Molecular Genetics

GO

Show Summary Details

Preview

Squamous cell carcinoma (SCC) constitutes a microenvironment that could modulate the antitumor immune response. Also, tumor-infiltrating lymphocytes are believed to play complex regulatory roles in antitumor immunity against SCC. The presence of regulatory T cells (Tregs) has been associated with the suppression of tumor-reactive T cells. However, the underlying mechanism for this T cell dysfunction is not clear. We used a multistage model of SCC to examine the role of Treg cells during tumor development. 7,12-dimethylbenz[a]-anthracene/phorbol 12-myristate 13-acetate treatment and systemic depletion of Treg cells using an anti-CD25 monoclonal antibody (PC61) resulted in a decrease in the number and incidence of papilloma. Furthermore, CD25 depletion increased the proportion of CD8+ and CD4+ T cells that were isolated from tumor lesions. The levels of interleukin (IL)-1β, IL-10, IL-12, IL-13, interferon-γ, transforming growth factor-β and tumor necrosis factor-α, but not IL-17, were increased in the tumor microenvironment after Treg depletion. Therefore, our results indicated involvement of CD25+ T cells in SCC development and in the suppression of the inflammatory immune response.

Journal Article.  4967 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.