Journal Article

Dynamic activation of the key pathways: linking colitis to colorectal cancer in a mouse model

Anliu Tang, Nan Li, Xiayu Li, Hongyuan Yang, Wei Wang, Liyang Zhang, Guiyuan Li, Wei Xiong, Jian Ma and Shourong Shen

in Carcinogenesis

Volume 33, issue 7, pages 1375-1383
Published in print July 2012 | ISSN: 0143-3334
Published online May 2012 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgs183
Dynamic activation of the key pathways: linking colitis to colorectal cancer in a mouse model

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An association between carcinogenesis and inflammation has long been appreciated. Chemically induced colitis-associated cancer (CAC) is a classical mouse model for investigating ‘inflammation–cancer link’ in the intestine. Diverse mechanisms behind this non-resolving inflammation model have been reported before, most of them were emphasized on key cancer genes, cytokines, and signal transduction abnormality based on prior knowledge. In this study, we dynamically and globally dissect the alteration of key pathways in the development from colitis to colorectal cancer. Striking evidence from gene expression profiling, serum cytokines detection, and immunohistochemistry analysis all reveals that different key pathways [NF-κB, STAT3, p38 mitogen-activated protein kinase (MAPK), and Wnt/β-catenin signaling] and their target genes are hyperactive in different phases of the inflammation–cancer link. Nuclear factor-κB (NF-κB) and STAT3 signaling are hyperactive in the whole process, while p38 MAPK and Wnt/β-catenin signaling are only hyperactive in the beginning and ending, respectively. Through this unbiased system biological approach, we provide strong evidence that different key pathways are specifically involved in different phases, which bridge the gap between inflammation and cancer.

Journal Article.  6096 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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