Journal Article

DNA methylation of microRNA genes in multiple myeloma

Kwan Yeung Wong, Xiaojun Huang and Chor Sang Chim

in Carcinogenesis

Volume 33, issue 9, pages 1629-1638
Published in print September 2012 | ISSN: 0143-3334
Published online August 2012 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgs212
DNA methylation of microRNA genes in multiple myeloma

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DNA methylation is one of the heritable epigenetic modifications, leading to repressed gene expressions and consequent phenotypic alterations without changing the DNA sequence. MicroRNA (miRNA) is a novel class of short non-coding RNA molecules regulating a wide range of cellular functions through translational repression of their target genes. Recently, epigenetic dysregulation of tumor-suppressor miRNA genes by promoter DNA methylation has been implicated in human cancers, including multiple myeloma (MM). This article presents a brief overview of the pathogenesis of MM, the role of DNA methylation in cancer biology, methods of DNA methylation analysis, miRNA biology and dysregulation of miRNAs in MM and summaries the current data on the role of DNA methylation of tumor-suppressive miRNAsin MM.

Journal Article.  8605 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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