Journal Article

Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells

Rachel A. Ridgway, Bryan Serrels, Susan Mason, Andrew Kinnaird, Morwenna Muir, Hitesh Patel, William J. Muller, Owen J. Sansom and Valerie G. Brunton

in Carcinogenesis

Volume 33, issue 12, pages 2369-2376
Published in print December 2012 | ISSN: 0143-3334
Published online September 2012 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgs284
Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells

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Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that integrates signals downstream of integrin and growth factor activation. Previously, we have shown that skin-specific loss of fak prevents chemically induced skin carcinogenesis in mice following phorbol ester treatment. In this study, we show that skin-specific deletion of fak prevents mobilization of stem cells within the bulge region of the hair follicle, which are the precursors of papillomas following phorbol ester treatment. We also show that phorbol ester treatment results in activation of-catenin within the skin and that FAK is required for β-catenin-induced stem cell mobilization. In addition, inhibition of Src kinase activity, a major binding partner of FAK also prevents stem cell mobilization. We show that FAK is required for the nuclear localization of β-catenin in the skin following phorbol ester treatment and the transcriptional activation of the β-catenin target gene c-Myc. This provides the first evidence of cross-talk between integrin and Wnt signalling pathways in the control of epidermal stem cells and the early events associated with skin carcinogenesis.

Journal Article.  5947 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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