Journal Article

Temporal and Cerebellar Brain Regions that Support both Declarative Memory Formation and Retrieval

Susanne Weis, Peter Klaver, Jürgen Reul, Christian E. Elger and Guillén Fernández

in Cerebral Cortex

Volume 14, issue 3, pages 256-267
Published in print March 2004 | ISSN: 1047-3211
Published online March 2004 | e-ISSN: 1460-2199 | DOI: http://dx.doi.org/10.1093/cercor/bhg125
Temporal and Cerebellar Brain Regions that Support both Declarative Memory Formation and Retrieval

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Using event-related fMRI, we scanned young healthy subjects while they memorized real-world photographs and subsequently tried to recognize them within a series of new photographs. We confirmed that activity in the medial temporal lobe (MTL) and inferior prefrontal cortex correlates with declarative memory formation as defined by the subsequent memory effect, stronger responses to subsequently remembered than forgotten items. Additionally, we confirmed that activity in specific regions within the parietal lobe, anterior prefrontal cortex, anterior cingulate and cerebellum correlate with recognition memory as measured by the conventional old/new effect, stronger responses for recognized old items (hits) than correctly identified new items (correct rejections). To obtain a purer measure of recognition success, we introduced two recognition effects by comparing brain responses to hits and old items misclassified as new (misses). The positive recognition effect (hits > misses) revealed prefrontal, parietal and cerebellar contributions to recognition, and in line with electrophysiological findings, the negative recognition effect (hits < misses) revealed an anterior medial temporal contribution. Finally, by inclusive masking, we identified temporal and cerebellar brain areas that support both declarative memory formation and retrieval. For matching operations during recognition, these areas may re-use representations formed and stored locally during encoding.

Keywords: declarative memory, event-related, fMRI, memory formation, recognition, retrieval

Journal Article.  8447 words.  Illustrated.

Subjects: Neuroscience

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