Journal Article

Hippocampal and Neocortical Gamma Oscillations Predict Memory Formation in Humans

Per B. Sederberg, Andreas Schulze-Bonhage, Joseph R. Madsen, Edward B. Bromfield, David C. McCarthy, Armin Brandt, Michele S. Tully and Michael J. Kahana

in Cerebral Cortex

Volume 17, issue 5, pages 1190-1196
Published in print May 2007 | ISSN: 1047-3211
Published online July 2006 | e-ISSN: 1460-2199 | DOI: http://dx.doi.org/10.1093/cercor/bhl030
Hippocampal and Neocortical Gamma Oscillations Predict Memory Formation in Humans

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Functional magnetic resonance imaging (fMRI) of the human brain has shown that the hippocampus and the left temporal and frontal cortices play a key role in the formation of new verbal memories. We recorded electrical activity from 2349 surgically implanted intracranial electrodes in epilepsy patients while they studied and later recalled lists of common words. Using these recordings, we demonstrate that gamma oscillations (44–64 Hz) in the hippocampus and the left temporal and frontal cortices predict successful encoding of new verbal memories. This increase in gamma oscillations was not seen in other frequency bands, whose activity generally decreased during successful memory formation. These findings identify a role for gamma oscillations in verbal memory formation with the hippocampus and the left temporal and frontal cortices, the same regions implicated using noninvasive fMRI recording methods.

Keywords: epilepsy; fMRI; free recall; gamma; iEEG; subsequent memory effect

Journal Article.  4359 words.  Illustrated.

Subjects: Neuroscience

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