Journal Article

Sall1 Regulates Mitral Cell Development and Olfactory Nerve Extension in the Developing Olfactory Bulb

Susan J. Harrison, Ryuichi Nishinakamura and A. Paula Monaghan

in Cerebral Cortex

Volume 18, issue 7, pages 1604-1617
Published in print July 2008 | ISSN: 1047-3211
Published online November 2007 | e-ISSN: 1460-2199 | DOI: http://dx.doi.org/10.1093/cercor/bhm191
Sall1 Regulates Mitral Cell Development and Olfactory Nerve Extension in the Developing Olfactory Bulb

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Sall1 is a zinc finger containing transcription factor that is highly expressed during mammalian embryogenesis. In humans, the developmental disorder Townes Brocks Syndrome is associated with mutations in the SALL1 gene. Sall1-deficient animals die at birth due to kidney deficits; however, its function in the nervous system has not been characterized. We examined the role of Sall1 in the developing olfactory system. We demonstrate that Sall1 is expressed by cells in the olfactory epithelium and olfactory bulb (OB). Sall1-deficient OBs are reduced in size and exhibit alterations in neurogenesis and mitral cell production. In addition, the olfactory nerve failed to extend past the ventral–medial region of the OB in Sall1-deficient animals. We observed intrinsic patterns of neurogenesis during olfactory development in control animals. In Sall1-mutant animals, these patterns of neurogenesis were disrupted. These findings suggest a role for Sall1 in regulating neuronal differentiation and maturation in developing neural structures.

Keywords: neurogenesis; olfactory nerve innervation; proliferation; spalt; Townes Brocks Syndrome

Journal Article.  12086 words.  Illustrated.

Subjects: Neuroscience

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