Journal Article

Ion Exclusion Chromatography of Aromatic Acids

Fotouh R. Mansour, Christine L. Kirkpatrick and Neil D. Danielson

in Journal of Chromatographic Science

Volume 51, issue 7, pages 655-665
Published in print August 2013 | ISSN: 0021-9665
Published online February 2013 | e-ISSN: 1945-239X | DOI:
Ion Exclusion Chromatography of Aromatic Acids

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The determination of aromatic acids by ion exclusion chromatography is challenging due to peak tailing and the long retention time of hydrophobic solutes. This review discusses the retention mechanisms and the factors affecting retention, eluents and detection methods used in ion exclusion chromatography of aromatic acids such as mono-, di-, tri- and tetra-carboxylic acids, amino acids, sulfonates and phenol. In addition, the different approaches used to improve the chromatographic separation of these compounds are also discussed. These approaches include introducing an internal gradient of the ionic strength, using vacancy ion exclusion chromatography, employing a hydrophilic cation exchange resin or adding a modifier such as heptanol to the dilute sulfuric acid mobile phase. The applications of these methods in the analysis of aromatic acids are provided with a table summarizing the stationary phases, the mobile phases and the detection methods.

Journal Article.  7170 words.  Illustrated.

Subjects: Chemistry

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