Journal Article

Implications of Isoniazid Resistance in <i>Mycobacterium bovis</i> Bacillus Calmette-Guérin used for Immunotherapy in Bladder Cancer

Matthew R Watts, Peter C Taylor, Vitali Sintchenko, Clair M Whelan, Robert H Farnsworth, Philip Jones, Peter Jelfs, David Carr and Hazel Goldberg

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 52, issue 1, pages 86-88
Published in print January 2011 | ISSN: 1058-4838
Published online January 2011 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1093/cid/ciq002
Implications of Isoniazid Resistance in Mycobacterium bovis Bacillus Calmette-Guérin used for Immunotherapy in Bladder Cancer

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We report a case of sepsis from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) with low-level isoniazid resistance following intravesical treatment for bladder cancer. Isoniazid resistance in BCG has therapeutic implications when it causes infections after intravesical instillation. For these circumstances, we propose some modifications to existing treatment guidelines for BCG infection.

Journal Article.  1499 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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