Journal Article

Virus Detection and Duration of Illness Among Patients With 2009 Pandemic Influenza A (H1N1) Virus Infection in Texas

Anil Suryaprasad, Oliver W. Morgan, Patrick Peebles, Agnes Warner, Tara K. Kerin, Mathew D. Esona, Michael D. Bowen, Wendy Sessions, Xiyan Xu, Theresa Cromeans, Fatimah Dawood, Trudi Shim, Manoj Menon, Jennifer R. Verani, Dean Erdman, Stephen Lindstrom, Vincent P. Fonseca, Alicia M. Fry and Sonja J. Olsen

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 52, issue suppl_1, pages S109-S115
Published in print January 2011 | ISSN: 1058-4838
Published online January 2011 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1093/cid/ciq014
Virus Detection and Duration of Illness Among Patients With 2009 Pandemic Influenza A (H1N1) Virus Infection in Texas

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Knowledge from early outbreaks is limited regarding the virus detection and illness duration of the 2009 pandemic influenza A (H1N1) infections. During the period from April to May 2009 in Texas, we collected serial nasopharyngeal (NP) and stool specimens from 35 participants, testing by real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) and culture. The participants were aged 2 months to 71 years; 25 (71%) were under 18. The median duration of measured fever was 3.0 days and of virus detection in NP specimens was 4.2 days; however, few specimens were collected between days 5–9. The duration of virus detection (4.2 days) was similar to the duration of fever (3.5 days) (RR, 1.14; 95% CI, .66–1.95; P = .8), but was shorter than the duration of cough (11.0 days) (RR, .41; 95% CI, .24–.68; P < .001). We detected viral RNA in two participants’ stools. All cultures were negative. This investigation suggests that the duration of virus detection was likely similar to the seasonal influenza virus.

Journal Article.  4138 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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