Journal Article

Hospitalized Patients with 2009 Pandemic Influenza A (H1N1) Virus Infection in the United States—September–October 2009

Jacek Skarbinski, Seema Jain, Anna Bramley, Esther J. Lee, Jean Huang, David Kirschke, Allison Stone, Tiffany Wedlake, Shawn M. Richards, Shannon Page, Patti Ragan, Lesley Bullion, Daniel Neises, Robin M. Williams, Bruno P. Petruccelli, Meredith Vandermeer, Kathryn H. Lofy, Jacqueline Gindler and Lyn Finelli

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 52, issue suppl_1, pages S50-S59
Published in print January 2011 | ISSN: 1058-4838
Published online January 2011 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1093/cid/ciq021
Hospitalized Patients with 2009 Pandemic Influenza A (H1N1) Virus Infection in the United States—September–October 2009

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Given the potential worsening clinical severity of 2009 pandemic influenza A (H1N1) virus (pH1N1) infection from spring to fall 2009, we conducted a clinical case series among patients hospitalized with pH1N1 infection from September through October 2009. A case patient was defined as a hospitalized person who had test results positive for pH1N1 virus by real-time reverse-transcription polymerase chain reaction. Among 255 hospitalized patients, 34% were admitted to an intensive care unit and 8% died. Thirty-four percent of patients were children <18 years of age, 8% were adults ≥65 years of age, and 67% had an underlying medical condition. Chest radiographs obtained at hospital admission that had findings that were consistent with pneumonia were noted in 103 (46%) of 255 patients. Among 255 hospitalized patients, 208 (82%) received neuraminidase inhibitors, but only 47% had treatment started ≤2 days after illness onset. Overall, characteristics of hospitalized patients with pH1N1 infection in fall 2009 were similar to characteristics of patients hospitalized with pH1N1 infection in spring 2009, which suggests that clinical severity did not change substantially over this period.

Journal Article.  6428 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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