Journal Article

Viral Shedding Duration of Pandemic Influenza A H1N1 Virus during an Elementary School Outbreak—Pennsylvania, May–June 2009

Achuyt Bhattarai, Julie Villanueva, Rakhee S. Palekar, Ryan Fagan, Wendy Sessions, Jörn Winter, LaShondra Berman, James Lute, Rebecca Leap, Tiffany Marchbanks, Samir V. Sodha, Mària Moll, Xiyan Xu, Alicia Fry, Anthony Fiore, Stephen Ostroff and David L. Swerdlow

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 52, issue suppl_1, pages S102-S108
Published in print January 2011 | ISSN: 1058-4838
Published online January 2011 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1093/cid/ciq026
Viral Shedding Duration of Pandemic Influenza A H1N1 Virus during an Elementary School Outbreak—Pennsylvania, May–June 2009

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We report shedding duration of 2009 pandemic influenza A (pH1N1) virus from a school-associated outbreak in Pennsylvania during May through June 2009. Outbreak-associated students or household contacts with influenza-like illness (ILI) onset within 7 days of interview were recruited. Nasopharyngeal specimens, collected every 48 hours until 2 consecutive nonpositive tests, underwent real-time reverse transcriptase polymerase chain reaction (rRT-PCR) and culture for pH1N1 virus. Culture-positive specimens underwent virus titrations. Twenty-six (median age, 8 years) rRT-PCR–positive persons, for pH1N1 virus, were included in analysis. Median shedding duration from fever onset by rRT-PCR was 6 days (range, 1–13) and 5 days (range, 1–7) by culture. Following fever resolution virus was isolated for a median of 2 days (range, 0–5). Highest and lowest virus titers detected, 2 and 5 days following fever onset, were 3.2 and 1.2 log10 TCID50/mL respectively. Overall, shedding duration in children and adults were similar to seasonal influenza viruses.

Journal Article.  3662 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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