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Clinicians frequently use influenza rapid antigen tests for diagnostic testing. We tested nasal wash samples from 1 April to 7 June 2009 from 1538 patients using the QuickVue Influenza A+B (Quidel) rapid influenza antigen test and compared the results with real-time reverse transcription polymerase chain reaction (rRT-PCR) assay (gold standard). The prevalence of 2009 pandemic influenza A (pH1N1) was 1.98%, seasonal influenza type A .87%, and seasonal influenza type B 2.07%. The sensitivity and specificity of the rapid test for pH1N1 was 20% (95% CI, 8–39) and 99% (95% CI, 98–99), for seasonal influenza type A 15% (95% CI, 2–45) and 99% (95% CI, 98–99), and for influenza type B was 31% (95% CI, 9–61) and 99% (95% CI, 98–99.7). Rapid influenza antigen tests were of limited use at a time when the prevalence of pH1N1 and seasonal influenza in the United States was low. Clinicians should instead rely on clinical impression and laboratory diagnosis by rRT-PCR.
Journal Article. 3960 words.
Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology
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