Journal Article

Improved Growth and Anemia in HIV-Infected African Children Taking Cotrimoxazole Prophylaxis

Andrew Prendergast, A. Sarah Walker, Veronica Mulenga, Chifumbe Chintu and Diana M. Gibb

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 52, issue 7, pages 953-956
Published in print April 2011 | ISSN: 1058-4838
Published online April 2011 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1093/cid/cir029
Improved Growth and Anemia in HIV-Infected African Children Taking Cotrimoxazole Prophylaxis

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The impact of cotrimoxazole (CTX) on growth and/or anemia was investigated in 541 human immunodeficiency virus-infected, antiretroviral therapy–naive Zambian children enrolled in the Children with HIV Antibiotic Prophylaxis trial. Compared with children randomized to receive placebo, children randomized to receive CTX had slower decreases in weight-for-age (P  =  .04) and height-for-age (P  =  .01), and greater increase in hemoglobin level (P  =  .01). These findings argue for expanded early CTX use.

Journal Article.  2318 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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