Journal Article

Reanalysis of Coreceptor Tropism in HIV-1–Infected Adults Using a Phenotypic Assay with Enhanced Sensitivity

Timothy J. Wilkin, Mathew Bidwell Goetz, Robert Leduc, Gail Skowron, Zhaohui Su, Ellen S. Chan, Jayyant Heera, Doug Chapman, John Spritzler, Jacqueline D. Reeves, Roy M. Gulick and Eoin Coakley

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 52, issue 7, pages 925-928
Published in print April 2011 | ISSN: 1058-4838
Published online April 2011 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1093/cid/cir072
Reanalysis of Coreceptor Tropism in HIV-1–Infected Adults Using a Phenotypic Assay with Enhanced Sensitivity

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The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1–infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.

Journal Article.  1991 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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