Journal Article

Enzyme-Linked Immunosorbent Assay for the Diagnosis of Melioidosis: Better Than We Thought

Direk Limmathurotsakul, Narisara Chantratita, Nittaya Teerawattanasook, Komson Piriyagitpaiboon, Aunchalee Thanwisai, Vanaporn Wuthiekanun, Nicholas P. J. Day, Ben Cooper and Sharon J. Peacock

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 52, issue 8, pages 1024-1028
Published in print April 2011 | ISSN: 1058-4838
Published online April 2011 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1093/cid/cir080

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We used Bayesian latent-class models to generate receiver operating characteristic curves and to revise the cutoff values for an enzyme-linked immosorbent assay that has been developed previously for melioidosis. The new cutoff was unbiased towards misclassification caused by an imperfect gold standard and resulted in an increase in both sensitivity (from 66.4% to 80.2%) and specificity (82.1% and 95.0%).

Journal Article.  2095 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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