Journal Article

Early Warning Indicators for Population-Based Monitoring of HIV Drug Resistance in 6 African Countries

Kim C. E. Sigaloff, Raph L. Hamers, Jack Menke, Moheb Labib, Margaret Siwale, Prudence Ive, Mariette E. Botes, Cissy Kityo, Kishor Mandaliya, Maureen Wellington, Akin Osibogun, Ronald B. Geskus, Wendy S. Stevens, Michèle van Vugt and Tobias F. Rinke de Wit

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 54, issue suppl_4, pages S294-S299
Published in print May 2012 | ISSN: 1058-4838
Published online May 2012 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1093/cid/cir1015
Early Warning Indicators for Population-Based Monitoring of HIV Drug Resistance in 6 African Countries

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Human immunodeficiency virus (HIV) RNA testing and HIV drug resistance (HIVDR) testing are not routinely available for therapeutic monitoring of patients receiving antiretroviral therapy (ART) in resource-limited settings. World Health Organization HIVDR early warning indicators (EWIs) assess ART site factors known to favor the emergence of HIVDR. HIV drug resistance EWI monitoring was performed within the PharmAccess African Studies to Evaluate Resistance Monitoring (PASER-M) study, comprising 13 ART sites in 6 African countries. Early warning indicator assessment in the PASER network identified vulnerable aspects of ART programs and triggered interventions aimed at minimizing HIVDR emergence. Additionally, data suggest an advantage of medication possession ratio over on-time antiretroviral drug pickup in identifying patients at risk for HIVDR development.

Journal Article.  3478 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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