Journal Article

Laboratory Methods for Determining Pneumonia Etiology in Children

David R. Murdoch, Katherine L. O’Brien, Amanda J. Driscoll, Ruth A. Karron and Niranjan Bhat

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 54, issue suppl_2, pages S146-S152
Published in print April 2012 | ISSN: 1058-4838
Published online April 2012 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1093/cid/cir1073
Laboratory Methods for Determining Pneumonia Etiology in Children

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Laboratory diagnostics are a core component of any pneumonia etiology study. Recent advances in diagnostic technology have introduced newer methods that have greatly improved the ability to identify respiratory pathogens. However, determining the microbial etiology of pneumonia remains a challenge, especially in children. This is largely because of the inconsistent use of assays between studies, difficulties in specimen collection, and problems in interpreting the presence of pathogens as being causally related to the pneumonia event. The laboratory testing strategy for the Pneumonia Etiology Research for Child Health (PERCH) study aims to incorporate a broad range of diagnostic testing that will be standardized across the 7 participating sites. We describe the current status of laboratory diagnostics for pneumonia and the PERCH approach for specimen testing. Pneumonia diagnostics are evolving, and it is also a priority of PERCH to collect and archive specimens for future testing by promising diagnostic methods that are currently under development.

Journal Article.  4461 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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