Journal Article

Adult Survivors of Invasive Pneumococcal Disease Exhibit Defective B Cell Function

Tom C. Darton, James B. Wing, Andrew Lees, Andrew W. Heath and Robert C. Read

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 52, issue 9, pages 1133-1136
Published in print May 2011 | ISSN: 1058-4838
Published online May 2011 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1093/cid/cir126
Adult Survivors of Invasive Pneumococcal Disease Exhibit Defective B Cell Function

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Adults who have recovered from an episode of invasive pneumococcal disease demonstrate defective B cell activation in response to αδ-dex, a polyclonal polysaccharide mimic, compared with matched control subjects. The defect is not overcome by CD4+ T cell assistance and may explain the relatively poor response to pneumococcal vaccination in survivors of invasive pneumococcal disease.

Journal Article.  1943 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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