Journal Article

Carbapenem-Resistant <i>Enterobacteriaceae</i>: Epidemiology and Prevention

Neil Gupta, Brandi M. Limbago, Jean B. Patel and Alexander J. Kallen

Edited by Robert A. Weinstein

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 53, issue 1, pages 60-67
Published in print July 2011 | ISSN: 1058-4838
Published online July 2011 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1093/cid/cir202
Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention

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Over the past 10 years, dissemination of Klebsiella pneumoniae carbapenemase (KPC) has led to an increase in the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Infections caused by CRE have limited treatment options and have been associated with high mortality rates. In the previous year, other carbapenemase subtypes, including New Delhi metallo-β-lactamase, have been identified among Enterobacteriaceae in the United States. Like KPC, these enzymes are frequently found on mobile genetic elements and have the potential to spread widely. As a result, preventing both CRE transmission and CRE infections have become important public health objectives. This review describes the current epidemiology of CRE in the United States and highlights important prevention strategies.

Journal Article.  4038 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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