Journal Article

Human Papillomavirus Vertical Transmission: Review of Current Data

A. C. Freitas, F. C. Mariz, M. A. R. Silva and A. L. S. Jesus

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 56, issue 10, pages 1451-1456
Published in print May 2013 | ISSN: 1058-4838
Published online February 2013 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1093/cid/cit066
Human Papillomavirus Vertical Transmission: Review of Current Data

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Despite the increasing evidence of human papillomavirus (HPV) vertical transmission, this route is regarded as less clinically important because of the detections of transient HPV DNA. However, recent studies have provided clear evidence of papillomavirus productive infection in lymphocytes, placenta, and bovine fetal tissue. Furthermore, a model of papillomavirus latency has been recently proposed that could explain the failure or transience in HPV detection observed in some infected infants. This new evidence of hematogeneous and vertical spread of HPV suggests that these modes of transmission should be investigated in greater detail to obtain a better understanding of the infection and a fuller awareness of the preventive measures that can be taken against HPV-related diseases.

Keywords: human papillomavirus; vertical transmission; human cancers; human papillomatosis

Journal Article.  3971 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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