Journal Article

High Rate of HIV Resuppression After Viral Failure on First-line Antiretroviral Therapy in the Absence of Switch to Second-line Therapy

Ravindra K. Gupta, Ruth L. Goodall, Michael Ranopa, Cissy Kityo, Paula Munderi, Fred Lyagoba, Lincoln Mugarura, Charles F. Gilks, Pontiano Kaleebu and Deenan Pillay

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 58, issue 7, pages 1023-1026
Published in print April 2014 | ISSN: 1058-4838
Published online December 2013 | e-ISSN: 1537-6591 | DOI:

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  • Infectious Diseases
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In a randomized comparison of nevirapine or abacavir with zidovudine plus lamivudine, routine viral load monitoring was not performed, yet 27% of individuals with viral failure at week 48 experienced resuppression by week 96 without switching. This supports World Health Organization recommendations that suspected viral failure should trigger adherence counseling and repeat measurement before a treatment switch is considered.

Keywords: HIV; failure; viral resuppression; resistance; Africa

Journal Article.  2963 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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