Journal Article

The Return of Delayed-Type Hypersensitivity Skin Testing for Coccidioidomycosis

Elizabeth E. Wack, Neil M. Ampel, Rebecca H. Sunenshine and John N. Galgiani

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 61, issue 5, pages 787-791
Published in print September 2015 | ISSN: 1058-4838
Published online May 2015 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1093/cid/civ388
The Return of Delayed-Type Hypersensitivity Skin Testing for Coccidioidomycosis

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A skin test that detects dermal hypersensitivity in persons with past infection with Coccidioides species is again available for clinical use. Nearly all of the clinical studies with similar materials were published prior to the 1990s, and as a result, many practicing physicians will be unfamiliar with how skin testing for coccidioidomycosis might be useful in patient management or as a research tool. We review clinical and epidemiological studies with past skin test antigens, the composition of past and current skin test preparations with particular attention to differences in the preservatives, and how the current preparation could be used today.

Keywords: coccidioidomycosis; delayed type hypersensitivity; skin test; cellular immunity; diagnostic test

Journal Article.  3692 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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