Journal Article

Discovery of Novel Transcription Control Relationships with Gene Regulatory Networks Generated from Multiple-disruption Full Genome Expression Libraries

Sachiyo Aburatani, Kosuke Tashiro, Christopher J. Savoie, Mayumi Nishizawa, Kaori Hayashi, Yuzuru Ito, Shigeru Muta, Kiyoshi Yamamoto, Miki Ogawa, Akiko Enomoto, Momoka Masaki, Shouji Watanabe, Yukihiro Maki, Yoriko Takahashi, Yukihiro Eguchi, Yoshiyuki Sakaki and Satoru Kuhara

in DNA Research

Published on behalf of Kazusa DNA Research Institute

Volume 10, issue 1, pages 1-8
Published in print January 2003 | ISSN: 1340-2838
Published online January 2003 | e-ISSN: 1756-1663 | DOI: http://dx.doi.org/10.1093/dnares/10.1.1

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Gene regulatory networks elucidated from strategic, genome-wide experimental data can aid in the discovery of novel gene function information and expression regulation events from observation of transcriptional regulation among genes of known and unknown biological function. To create a reliable and comprehensive data set for the elucidation of transcription regulation networks, we conducted systematic genome-wide disruption expression experiments of yeast on 118 genes with known involvement in transcription regulation. We report several novel regulatory relationships between known transcription factors and other genes with previously unknown biological function discovered with this expression library. Here we report the downstream regulatory subnetworks for UME6 and MET28. The elucidated network topology among these genes demonstrates MET28's role as a nodal point between genes involved in cell division and those involved in DNA repair mechanisms.

Keywords: expression data; disruptant; gene regulatory network; MET28 regulation

Journal Article.  0 words. 

Subjects: Genetics and Genomics

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