Journal Article

Polymorphic 33-bp Repeats with Promoter-like Activity in Synaptotagmin 11 Gene

Hiroshi Yokota, Takahiro Tsujita, Yuji Okazaki, Eriko Kikuya and Michio Oishi

in DNA Research

Published on behalf of Kazusa DNA Research Institute

Volume 10, issue 6, pages 287-289
Published in print January 2003 | ISSN: 1340-2838
Published online January 2003 | e-ISSN: 1756-1663 | DOI: http://dx.doi.org/10.1093/dnares/10.6.287

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In the immediate upstream region of the transcription initiation site of human synaptotagmin 11 gene, we found a tandem repeat of a 33-bp unit with a promoter-like activity. The tandem repeat is apparently polymorphic in the Japanese population as two DNA samples from 60 schizophrenia patients exhibited an increased number (three) of the unit. In a transfection assay using constructs with different numbers of repeats, the promoter-like activity was found to increase with the number of repeating unit.

Keywords: tandem repeat; polymorphism; schizophrenia; gene expression

Journal Article.  0 words. 

Subjects: Genetics and Genomics

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