Journal Article

A Comprehensive Approach for Establishment of the Platform to Analyze Functions of KIAA Proteins II: Public Release of Inaugural Version of InGaP Database Containing Gene/Protein Expression Profiles for 127 Mouse KIAA Genes/Proteins

Hisashi Koga, Shigeki Yuasa, Takahiro Nagase, Kiyo Shimada, Mihoko Nagano, Kazuhide Imai, Reiko Ohara, Daisuke Nakajima, Masatoshi Murakami, Makoto Kawai, Futaba Miki, Junji Magae, Susumu Inamoto, Noriko Okazaki and Osamu Ohara

in DNA Research

Published on behalf of Kazusa DNA Research Institute

Volume 11, issue 4, pages 293-304
Published in print January 2004 | ISSN: 1340-2838
Published online January 2004 | e-ISSN: 1756-1663 | DOI: http://dx.doi.org/10.1093/dnares/11.4.293

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The inaugural version of the InGaP database (Integrative Gene and Protein expression database; ) is a comprehensive database of gene/protein expression profiles of 127 mKIAA genes/proteins related to hypothetical ones obtained in our ongoing cDNA project. Information about each gene/protein consists of cDNA microarray analysis, subcellular localization of the ectopically expressed gene, and experimental data using anti-mKIAA antibody such as Western blotting and immunohistochemical analyses. KIAA cDNAs and their mouse counterparts, mKIAA cDNAs, were mainly isolated from cDNA libraries derived from brain tissues, thus we expect our database to contribute to the field of neuroscience. In fact, cDNA microarray analysis revealed that nearly half of our gene collection is predominantly expressed in brain tissues. Immunohistochemical analysis of the mouse brain provides functional insight into the specific area and/or cell type of the brain. This database will be a resource for the neuroscience community by seamlessly integrating the genomic and proteomic information about the mouse KIAA genes/proteins.

Keywords: mKIAA; database; antibody; cDNA microarray

Journal Article.  0 words. 

Subjects: Genetics and Genomics

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