Journal Article

The Nucleotide Sequence of Human Acylamino Acid-Releasing Enzyme

Masanori Mitta, Hiroshi Ohnogi, Shigetoshi Mizutani, Fumio Sakiyama, Ikunoshin Kato and Susumu Tsunasawa

in DNA Research

Published on behalf of Kazusa DNA Research Institute

Volume 3, issue 1, pages 31-35
Published in print January 1996 | ISSN: 1340-2838
Published online January 1996 | e-ISSN: 1756-1663 | DOI: http://dx.doi.org/10.1093/dnares/3.1.31

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The nucleotide sequence of a cDNA coding for the human acylamino acid-releasing enzyme (AARE, also known as acylpeptide hydrolase) [EC 3.4.19.1] subunit has been determined. The amino acid sequence of human AARE subunit deduced from its cDNA nucleotide sequence showed a high degree of identity (91.5%) with both the corresponding proteins from the pig and the rat. The AARE cDNA shows 99.2% identity with a 3.3 kb cDNA transcribed from a locus (DNF15S2) on the short arm of human chromosome 3, whose deletion is associated with small cell lung cancer, taking into consideration that the sequence of the 3.3-kb cDNA previously reported was caused by misreading.

Keywords: Acylamino Acid-Releasing Enzyme; cDNA sequence; N-teminal acetylation; Small cell lung cancer

Journal Article.  0 words. 

Subjects: Genetics and Genomics

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