Journal Article

Five Candidate Genes for Hamster Cardiomyopathy Did not Map to the Cardiomyopathy Locus by FISH Analysis

Shuji Takada, Yasushi Okazaki, Mamoru Kamiya, Tomoya Ohsumi, Osamu Nomura, Hisato Okuizumi, Nobuya Sasaki, Hideo Shibata, Masayuki Mori, Masahiko Nishimura, Masami Muramatsu, Yoshihide Hayashizaki and Yoichi Matsuda

in DNA Research

Published on behalf of Kazusa DNA Research Institute

Volume 3, issue 4, pages 273-276
Published in print January 1996 | ISSN: 1340-2838
Published online January 1996 | e-ISSN: 1756-1663 | DOI: http://dx.doi.org/10.1093/dnares/3.4.273

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The Syrian cardiomyopathic hamster (BIO14.6), that develops both muscular dystrophy and progressive cardiomyopathy, is widely used as an animal model of autosomal recessive cardiomyopathy mimicking human hypertrophic cardiomyopathy, and five genes have been proposed as strong candidates for the cause of cardiomyopathy. We recently mapped the cardiomyopathy locus of the hamster to the centromeric region of chromosome 9qa2.1-b1 by construction of a genetic linkage map of the Syrian hamster. Thus, we analyzed the loci of the five candidate genes, α tropomyosin, cardiac troponin T, adhalin, calpain 3 and cardiac myosin binding protein-C, by the FISH method, and found that these genes were mapped on the distal portion of chromosome 12qa5 and 4pa2 and the proximal portion of chromosomes 9qb7, 1qc1.1 and 1qb3, respectively. These results provide strong evidence that the five candidate genes previously proposed are not related to the hamster cardiomyopathy.

Keywords: cardiomyopathic hamster (BIO14.6); hypertrophic cardiomyopathy; muscular dystrophy; FISH; chromosomal location

Journal Article.  0 words. 

Subjects: Genetics and Genomics

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