Journal Article

The Primary Structure and Genomic Organization of Five Novel Transcripts Located Close to the Huntington's Disease Gene on Human Chromosome 4p16.3

Shinji Hadano, Yoshikazu Ishida and Joh-E. Ikeda

in DNA Research

Published on behalf of Kazusa DNA Research Institute

Volume 5, issue 3, pages 177-186
Published in print January 1998 | ISSN: 1340-2838
Published online January 1998 | e-ISSN: 1756-1663 | DOI: http://dx.doi.org/10.1093/dnares/5.3.177

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Five distinct noveltranscripts (RES4-22, -23, -24, -25 and -26) that mapped to the 1-Mb interval between D4S180 and D4S183 on human chromosome 4p16.3 close to the Huntington's disease (HD) gene were isolated, and the structure and exon/intron organization of each gene were thoroughly analyzed. The transcripts of the RES4-22, -23 and -24 genes each have several isoforms by alternative splicing and these have also been defined. Two transcripts, RES4-24 and RES4-25, reside in the same genomic region with opposite polarities and they also clearly overlap. Among these transcripts, RES4-26 was found to encode a novel zinc finger protein. The transcript map based upon our current level of analysis combined with data from previous studies reveals the gene-rich nature and the intricate organization of the genes in the HD locus.

Keywords: novel transcript; transcript map; human chromosome 4p16.3; Huntington's disease

Journal Article.  0 words. 

Subjects: Genetics and Genomics

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