Journal Article

Genomic Organization and Localization of the Human CRMP-1 Gene

Rosarelis Torres and Mihael H. Polymeropoulos

in DNA Research

Published on behalf of Kazusa DNA Research Institute

Volume 5, issue 6, pages 393-395
Published in print January 1998 | ISSN: 1340-2838
Published online January 1998 | e-ISSN: 1756-1663 | DOI: http://dx.doi.org/10.1093/dnares/5.6.393

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The Collapsin Response Mediator Protein-1 (CRMP-1) is a brain specific protein considered to be involved in the collapsin-induced growth cone collapse during neural development. CRMP-1 belongs to the Unc-33 gene family. Here we report the genomic structure and the localization of the human CRMP-1 gene to chromosome 4p16.1. Sequence analysis revealed that the human CRMP-1 gene consists of 14 exons. We have also established sequencing assays for all its coding exons. This should permit the rapid screening for mutations to assess CRMP-1 role in genetic disorders mapped in the 4p16.1 region.

Keywords: Human CRMP-1 gene; gene mapping; Exon-intron structure

Journal Article.  0 words. 

Subjects: Genetics and Genomics

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