Journal Article

Method Revealing Latent Periodicity of the Nucleotide Sequences Modified for a Case of Small Samples

Maria B. Chaley, Eugene V. Korotkov and Konstantin G. Skryabin

in DNA Research

Published on behalf of Kazusa DNA Research Institute

Volume 6, issue 3, pages 153-163
Published in print January 1999 | ISSN: 1340-2838
Published online January 1999 | e-ISSN: 1756-1663 | DOI:

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An earlier reported method for revealing latent periodicity of the nucleotide sequences has been considerably modified in a case of small samples, by applying a Monte Carlo method. This improved method has been used to search for the latent periodicity of some nucleotide sequences of the EMBL data bank. The existence of the nucleotide sequences' latent periodicity has been shown for some genes. The results obtained have implied that periodicity of gene structure is projected onto the periodicity of primary amino acid sequences and, further, onto spatial protein conformation. Even though the periodic structure of gene sequences has been eroded, it is still retained in primary and/or spatial structures of corresponding proteins. Furthermore, in a few cases the study of genes' periodicity has suggested their possible evolutionary origin by multifold duplications of some gene's fragments.

Keywords: computer sequence analysis; latent periodicity; gene structure; protein structure; relationship between gene and protein structures

Journal Article.  0 words. 

Subjects: Genetics and Genomics

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