Journal Article

Genomic Structure of an Economically Important Cyanobacterium, <i>Arthrospira</i> (<i>Spirulina</i>) <i>platensis</i> NIES-39

Takatomo Fujisawa, Rei Narikawa, Shinobu Okamoto, Shigeki Ehira, Hidehisa Yoshimura, Iwane Suzuki, Tatsuru Masuda, Mari Mochimaru, Shinichi Takaichi, Koichiro Awai, Mitsuo Sekine, Hiroshi Horikawa, Isao Yashiro, Seiha Omata, Hiromi Takarada, Yoko Katano, Hiroki Kosugi, Satoshi Tanikawa, Kazuko Ohmori, Naoki Sato, Masahiko Ikeuchi, Nobuyuki Fujita and Masayuki Ohmori

in DNA Research

Published on behalf of Kazusa DNA Research Institute

Volume 17, issue 2, pages 85-103
Published in print April 2010 | ISSN: 1340-2838
Published online March 2010 | e-ISSN: 1756-1663 | DOI: http://dx.doi.org/10.1093/dnares/dsq004

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A filamentous non-N2-fixing cyanobacterium, Arthrospira (Spirulina) platensis, is an important organism for industrial applications and as a food supply. Almost the complete genome of A. platensis NIES-39 was determined in this study. The genome structure of A. platensis is estimated to be a single, circular chromosome of 6.8 Mb, based on optical mapping. Annotation of this 6.7 Mb sequence yielded 6630 protein-coding genes as well as two sets of rRNA genes and 40 tRNA genes. Of the protein-coding genes, 78% are similar to those of other organisms; the remaining 22% are currently unknown. A total 612 kb of the genome comprise group II introns, insertion sequences and some repetitive elements. Group I introns are located in a protein-coding region. Abundant restriction-modification systems were determined. Unique features in the gene composition were noted, particularly in a large number of genes for adenylate cyclase and haemolysin-like Ca2+-binding proteins and in chemotaxis proteins. Filament-specific genes were highlighted by comparative genomic analysis.

Keywords: cyanobacteria; Arthrospira; health supplement; genome; cAMP

Journal Article.  10567 words.  Illustrated.

Subjects: Genetics and Genomics

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