Journal Article

Effect of low-dose testosterone treatment on craniofacial growth in boys with delayed puberty

A Verdonck, M Gaethofs, C Carels and F de Zegher

in The European Journal of Orthodontics

Published on behalf of European Orthodontics Society

Volume 21, issue 2, pages 137-143
Published in print April 1999 | ISSN: 0141-5387
Published online April 1999 | e-ISSN: 1460-2210 | DOI:
Effect of low-dose testosterone treatment on craniofacial growth in boys with delayed puberty

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Craniofacial growth was investigated in boys treated with low-dose testosterone for delayed puberty (>14 years old; testicular volume <4 ml; n=7) and compared with controls (12-14 years; n=37). Cephalometric radiographs, statural height and pubertal stage were recorded at the start of the study and after 1 year. Craniofacial growth was assessed by nine linear measurements.

At the beginning of the study, statural height, mandibular ramus length, upper anterior face height, and total cranial base length were significantly shorter in the delayed puberty boys than in the controls. After 1 year, the growth rate of the statural height, total mandibular length, ramus length, and upper and total anterior face height was significantly higher in the treated boys than in the untreated height-matched controls (n=7). The craniofacial measurements were similar in the treated boys as compared with the controls.

These results show that statural height and craniofacial dimensions are low in boys with delayed puberty. Low doses of testosterone accelerate statural and craniofacial growth, particularly in the delayed components, thus leading towards a normalization of facial dimensions.

Journal Article.  0 words. 

Subjects: Restorative Dentistry and Orthodontics

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